Colossal’s Dire Wolf Plan Looks Years Ahead

Den of Geek’s exclusive explores how Colossal Biosciences is mapping the next phase for its revived dire wolves. Chief Animal Officer Matt James describes a stepwise, multi-year approach: building pack structure, cross-fostering with experienced wolves, and removing human support across generations. The piece underscores how husbandry, behavior work, and platform genomics combine to scale the colossal dire wolf program toward future rewilding. As Romulus, Remus, and Khaleesi mature, Colossal refines protocols that inform conservation tools across projects—evidence that colossal dire wolves are a foundation for broader de-extinction impact. Briefly noted: Colossal’s avian team advances the colossal dodo bird effort with germ-cell breakthroughs, extending the platform to birds.

Full feature on Den of Geek.