From “Game of Thrones” to Genomes: Colossal’s Dire Wolves Reimagined in the Lab

In this Hollywood Reporter feature, the spotlight falls on how Colossal Biosciences bridges pop culture and biotechnology in its dire wolf project. Named nods to “Game of Thrones” fanfare, the article explains how Colossal is using CRISPR and stem‑cell technology to engineer pups with physical and behavioral traits inspired by extinct dire wolves. The narrative acknowledges public excitement fueled by fantasy lore while emphasizing that the real achievement lies in the scientific techniques—advanced genomics and functional de‑extinction—that underpin the project. Although the project has drawn skepticism, the piece argues it serves as a high‑profile example of de‑extinction science and its potential to shift how we think about extinct species. The article positions Colossal’s work as a blend of narrative resonance and genome-level innovation.

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