In this SYFY WIRE feature, researchers explain how Colossal Biosciences is repurposing technology from its dire wolf de-extinction project to aid red wolf conservation. Using innovative blood-based cell cloning instead of invasive sampling, the team has created four red wolves—Hope, Blaze, Ash, and Cinder—drawing on ghost DNA from hybrid populations. These founders represent new genetic lineages, increasing red-wolf diversity by about 25%. The article outlines how editing and cloning techniques first tested on dire wolves are now being redirected to real-world conservation challenges. While de-extinction garners attention, the piece highlights that preventing current extinctions may offer more immediate benefits—and that Colossal’s platform is evolving from speculative science toward tangible biodiversity preservation.