Dire Wolf De-Extinction: Inside Newsweek’s Look at Colossal’s Genetic Breakthrough

In this Newsweek feature, Colossal Biosciences shares how its team used ancient DNA and gene editing to create three pups—Romulus, Remus, and Khaleesi—with traits modeled after the extinct dire wolf. By introducing 20 targeted edits across 14 genetic loci, the company aims to develop a new canid lineage with phenotypic and behavioral similarities to the iconic Ice Age predator. The article highlights both the scientific achievement and the evolving conversation around what defines de-extinction. While some experts emphasize the importance of clear terminology, Colossal maintains that the pups represent a meaningful step forward in functional de-extinction. The piece ultimately frames the effort as part of a broader push to use biotechnology not only to revive lost traits, but to inform the future of conservation science.

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