‘Game of Thrones’ Just Got Real: Scientists Brought Back Actual Dire Wolves Using Ancient DNA

Colossal Biosciences—aka the startup that wants to make extinction optional—has officially resurrected a prehistoric predator best known for its role in Game of Thrones. Yes, dire wolves are real. And yes, they’re back.

In the world of Game of Thrones, dire wolves are massive, ancient beasts bonded to the Stark family like oversized emotional support dogs. In real life (yes, they existed once, about 12,000 years ago), they were even more intimidating—bigger than modern wolves, with broad chests, thick skulls, and bone-crushing jaws built for prehistoric carnage. And now, thanks to a Dallas-based biotech startup that sounds like it was dreamed up in a Marvel origin story, dire wolves are officially back.

Colossal Biosciences—the company whose mission is “de-extinction”—has pulled off one of the wildest feats in modern science: using ancient DNA and CRISPR gene editing to resurrect the dire wolf. Today, the company announced the birth of three living, breathing dire wolves: Romulus, Remus, and, fittingly, Khaleesi.

This isn’t CGI. It’s not AI-generated. It’s science that reads like science fiction—powered by gene editing, ancient fossils, and the kind of tech you’d expect to see in Tony Stark’s lab. These are actual, giant, genetically accurate, scientifically verified dire wolves walking the Earth again. The kind of reveal that makes you double-take and ask, “Wait, this isn’t just a GoT promo?”

Nope. This is very real. And it might be the most bonkers science story of the year.

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